Properties of heparin-poly (methyl methacrylate) copolymers. II

✍ Scribed by Labarre, D. ;Jozefowicz, M. ;Boffa, M. C.

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 453 KB
• Volume: 11
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820110212

✦ Synopsis

Abstract

A heparin–poly (methyl methacrylate) copolymer in which heparin has been covalently bound was studied. This copolymer showed no release of heparin but presented heparin‐like anticoagulant activity when suspended in plasma. After contact with plasma, the copolymer lost part of its antithrombin activity which could be restored by a high ionic‐strength medium. Because of its solid form, this copolymer offers new possibilities for producing interesting anticoagulant surfaces.