Chlorotrimethylsilane -sodium iodide reagent (in situ generation of iodotrimethylsilane)in acetonitrile reduces alkyl and aryl/aroyl azides to the corresponding amines/amides in excellent yields under neutral and mild conditions.
Propane-1,3-dithiol: A selective reagent for the efficient reduction of alkyl and aryl azides to amines
β Scribed by Hagan Bayley; David N. Standring; Jeremy R. Knowles
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- French
- Weight
- 156 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Iodotrimethylsilane: A Mild and Efficient Reagent for the Reduction of Azides to Amines. -An efficient and chemoselective protocol for the reduction of azides using in situ prepared iodotrimethylsilane as a reducing agent is reported. The corresponding amines are formed in excellent yields. -
Treatment of Sn(SPh)z with PhSH and Et3N affords a tin(II) complex, soluble in organic solvents, which is the best reducing agent for azides reported so far. Bu2SnH2. although not so reactive, also shows several advantages with regard to the standard reducing agents for azides. such as its solubilit