Serial passage of the MS-1 strain hepatitis A virus (HAV) in marmosets was shown to increase the yield of virus and to shorten the incubation period from approximately 55 days in the first passage to 3-7 days in the ninth and higher passages. Intravenous inoculation of susceptible chimpanzees with M
✦ LIBER ✦
Propagation and assay of hepatitis A virus in vitro
✍ Scribed by Günter Siegl; José Dechastonay; Gertrud Kronauer
- Book ID
- 119114213
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 1013 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0166-0934
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## Abstract Human diploid fibroblasts and human primary liver cell carcinoma cells (PLC/PRF/5) were infected with hepatitis A virus (HAV) adapted to growth in cell culture or derived directly from human stool. Viral antigen was expressed in PLC/PRF/5 cells 28 days after infection with cell culture‐