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Promoter-specific p53-dependent histone acetylation following DNA damage

✍ Scribed by Kaeser, Matthias D; Iggo, Richard D

Book ID
110068611
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
295 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract We have addressed the correlation between sequence‐specific DNA binding by the tumor suppressor p53 and transactivation of various target genes, in the context of UV irradiation responses. In A549 cells (p53WT), p53 occupancy at the __p21__, __mdm2__, and __puma__ promoters increased si