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Promoter hypermethylation (PM) of the tumor-suppressor genes p16INK4A and p14ARF during neoplastic progression in long-standing ulcerative colitis (UC)

✍ Scribed by Klump, Bodo; Hsieh, Chih-Jen; Holzmann, Karlheinz; Nehls, Oliver; Gaco, Veronika; Gregor, Michael

Book ID
124145339
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
185 KB
Volume
120
Category
Article
ISSN
0016-5085

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## Abstract Aberrant promoter methylation is an important mechanism for gene silencing. In the present study, 50 Barrett's esophagus‐associated esophageal adenocarcinomas (ADC), 50 cardiac ADC and 50 gastric ADC were investigated by means of methylation‐specific real‐time PCR for hypermethylation i