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Promoter hypermethylation of the tumor suppressor gene p16/INK4A during neoplastic progression in ulcerative colitis

โœ Scribed by Hsieh, CJ; Klump, B.; Holzmann, K.; Borchard, F.; Gregor, M.; Porschen, R.


Book ID
122830992
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
157 KB
Volume
114
Category
Article
ISSN
0016-5085

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Hypermethylation of tumor suppressor gen
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## Abstract Aberrant promoter methylation is an important mechanism for gene silencing. In the present study, 50 Barrett's esophagusโ€associated esophageal adenocarcinomas (ADC), 50 cardiac ADC and 50 gastric ADC were investigated by means of methylationโ€specific realโ€time PCR for hypermethylation i