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Promoter Analysis of MouseScn3aGene and Regulation of the Promoter Activity by GC Box and CpG Methylation

✍ Scribed by Guang-Fei Deng; Jia-Ming Qin; Xun-Sha Sun; Zu-Ying Kuang; Tao Su; Qi-Hua Zhao; Yi-Wu Shi; Xiao-Rong Liu; Mei-Juan Yu; Yong-Hong Yi; Wei-Ping Liao; Yue-Sheng Long

Book ID
107575431
Publisher
Humana Press Inc
Year
2011
Tongue
English
Weight
298 KB
Volume
44
Category
Article
ISSN
0895-8696

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## Abstract Metallothioneins (MTs) are a group of cysteine‐rich stress response proteins that scavenge reactive oxygen species and heavy metals. Recently, we have shown that MT‐I promoter is methylated and suppressed in some solid and liquid tumors and can be robustly activated following treatment