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Prolyl 4-hydroxylases, master regulators of the hypoxia response

✍ Scribed by Myllyharju, J.

Book ID
127114628
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
453 KB
Volume
208
Category
Article
ISSN
1748-1708

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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1Ξ± and HIF‐2Ξ±) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen