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Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

✍ Scribed by Kiichi Hirota; Gregg L. Semenza


Book ID
116291320
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
173 KB
Volume
338
Category
Article
ISSN
0006-291X

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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1Ξ± and HIF‐2Ξ±) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen