No effective therapy has yet developed for liver fibro-Among the different causes of liver cirrhosis, one sis by directory inhibiting the accumulation of extracelcommon feature is an increased deposition of extracellular matrix. The effect of a newly synthesized prolyl lular matrix, which consists m
β¦ LIBER β¦
Prolyl 4-hydroxylase inhibitor (HOE 077) preventsTIMP-1gene expression in rat liver fibrosis
β Scribed by Isao Sakaida; Koichi Uchida; Koji Hironaka; Kiwamu Okita
- Book ID
- 106181117
- Publisher
- Springer Japan
- Year
- 1999
- Tongue
- English
- Weight
- 59 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0944-1174
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Fibrosis and cirrhosis of the liver are often the result of chronic liver damage by a variety of different agents. Pathological accumulation of collagen, disruption of the lobular structure, and impaired hepatocellular function frequently lead to systemic involvement and fatal complications. Drugs i