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Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors

โœ Scribed by Forrest L Smith; Ruby Javed; Mark J Elzey; Sandra P Welch; Dana Selley; Laura Sim-Selley; William L Dewey


Book ID
118518968
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
378 KB
Volume
958
Category
Article
ISSN
0006-8993

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## Abstract ## Background Although morphine is a widely used opioid analgesic, morphine tolerance (MT) has limited the use of the drug because it creates the necessity for high doses. Protein kinase C (PKC), especially the PKCฮณ isoform, is considered to play a key role in the development of MT. Be