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Prolonged exposure to acid and bile induces chromosome abnormalities that precede malignant transformation of benign Barrett’s epithelium

✍ Scribed by Manisha Bajpai, Hana Aviv, Kiron M Das

Book ID
120698085
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
236 KB
Volume
5
Category
Article
ISSN
1755-8166

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Transformation of benign Barrett's epith
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✍ Kiron M. Das; Yingxin Kong; Manisha Bajpai; Diptee Kulkarni; Xin Geng; Pravin Mi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 743 KB

## Abstract The mechanism by which gastroesophageal reflux promotes metaplasia→dysplasia→carcinoma is unknown. The aim of the study is to determine if repeated exposure to acid and bile confers a tumorigenic phenotype in a telomerase (hTERT)‐immortalized benign Barrett's cell line (BAR‐T). BAR‐T ce