899 Transformation of Benign Barrett's Epithelial Cells By Repeated Acid and Bile Exposure Over 22-65 Weeks: An in-Vitro Model of Metaplasia to Neoplasia By Environmental Factors

Transformation of benign Barrett's epith

Transformation of benign Barrett's epithelium by repeated acid and bile exposure over 65 weeks: A novel in vitro model

✍ Kiron M. Das; Yingxin Kong; Manisha Bajpai; Diptee Kulkarni; Xin Geng; Pravin Mi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 743 KB

## Abstract The mechanism by which gastroesophageal reflux promotes metaplasia→dysplasia→carcinoma is unknown. The aim of the study is to determine if repeated exposure to acid and bile confers a tumorigenic phenotype in a telomerase (hTERT)‐immortalized benign Barrett's cell line (BAR‐T). BAR‐T ce