Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs
β Scribed by Dumont, J. A.; Liu, T.; Low, S. C.; Zhang, X.; Kamphaus, G.; Sakorafas, P.; Fraley, C.; Drager, D.; Reidy, T.; McCue, J.
- Book ID
- 111891184
- Publisher
- American Society of Hematology
- Year
- 2012
- Tongue
- English
- Weight
- 286 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0006-4971
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Recombinant human factor VIII (rFVIII), a multidomain glycoprotein is used in replacement therapy for treatment of hemophilia A. Unfortunately, 15%-30% of the treated patients develop inhibitory antibodies. The pathogenesis of antibody development is not completely understood. The presence of aggreg
Factor VIII is a multi-domain glycoprotein and is an essential cofactor in the blood coagulation cascade. Its deficiency or dysfunction causes Hemophilia A, a bleeding disorder. Replacement using exogenous recombinant Factor VIII (FVIII) is the first line of therapy for Hemophilia A. Immunogenicity,