## Abstract Reduction in the antiparkinsonian benefit of levodopa is a major complication of long‐term levodopa treatment in advanced Parkinson's disease (PD). Such loss of benefit arises because of reduced duration of action and appearance of disabling dyskinesia. We assess the potential of the α~
✦ LIBER ✦
Prolongation of levodopa responses by glycineB antagonists in parkinsonian primates
✍ Scribed by Stella M. Papa; Yves P. Auberson; J. Timothy Greenamyre
- Book ID
- 101466450
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 163 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Enkephalin is reported to play an important role in the pathophysiology of levodopa (LD) ‐induced dyskinesias. The present study investigated the effect of chronic treatment with a selective NR1A/2B __N__‐methyl‐D‐aspartate (NMDA) receptor antagonist, CI‐1041, on the expression of prepr