Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease
β Scribed by Pierre J. Blanchet; Stella M. Papa; Leo Verhagen Metman; M.Maral Mouradian; Thomas N. Chase
- Book ID
- 108403335
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 827 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0149-7634
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## Abstract Opioid peptide transmission is enhanced in the striatum of animal models and Parkinson's disease (PD) patients with levodopaβinduced motor complications. Opioid receptor antagonists reduce levodopaβinduced dyskinesia in primate models of PD; however, clinical trials to date have been in
## Abstract In this prospective study of 34 patients with Parkinson's disease, measurements of the short duration levodopa motor response have been performed in defined __off__ states at 3 yearly intervals over a mean period of 11.4 years from the point of commencement of levodopa treatment. Twenty