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Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease

✍ Scribed by Frédéric Calon; Ali H Rajput; Oleh Hornykiewicz; Paul J Bédard; Thérèse Di Paolo


Book ID
116761487
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
607 KB
Volume
14
Category
Article
ISSN
0969-9961

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## Abstract Opioid peptide transmission is enhanced in the striatum of animal models and Parkinson's disease (PD) patients with levodopa‐induced motor complications. Opioid receptor antagonists reduce levodopa‐induced dyskinesia in primate models of PD; however, clinical trials to date have been in