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Proline-Directed Random-Coil Chemical Shift Values as a Tool for the NMR Assignment of the Tau Phosphorylation Sites

✍ Scribed by Guy Lippens; Jean-Michel Wieruszeski; Arnaud Leroy; Caroline Smet; Alain Sillen; Luc Buée; Isabelle Landrieu


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
18 KB
Volume
5
Category
Article
ISSN
1439-4227

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Proline-Directed Random-Coil Chemical Sh
✍ Guy Lippens; Jean-Michel Wieruszeski; Arnaud Leroy; Caroline Smet; Alain Sillen; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

## Abstract __NMR spectroscopy of the full‐length neuronal Tau protein has proved to be difficult due to the length of the protein and the unfavorable amino acid composition. We show that the random‐coil chemical shift values and their dependence on the presence of a proline residue in the (__i__+1