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Proline-Based Macrocyclic Inhibitors of the Hepatitis C Virus: Stereoselective Synthesis and Biological Activity

✍ Scribed by Kevin X. Chen; F. George Njoroge; Bancha Vibulbhan; Andrew Prongay; John Pichardo; Vincent Madison; Alexei Buevich; Tze-Ming Chan

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
312 KB
Volume
44
Category
Article
ISSN
0044-8249

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Solid phase synthesis of peptide aldehyd
Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein
✍ Nicholas J. Ede; Susan N. Eagle; Geoffrey Wickham; Andrew M. Bray; Bob Warne; Ke πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 132 KB

The solid phase synthesis of a set of peptide aldehydes derived from the NS5A/NS5B junction of hepatitis C virus (HCV) viral polyprotein is demonstrated using an oxazolidine linker and the Multipinβ„’ method. Deletion of the P6 and P5 residues results in a dramatic loss of inhibitory activity.