✦ LIBER ✦

Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein

✍ Scribed by Nicholas J. Ede; Susan N. Eagle; Geoffrey Wickham; Andrew M. Bray; Bob Warne; Kevin Shoemaker; Steve Rosenberg

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 132 KB
Volume: 6
Category: Article
ISSN: 1075-2617
DOI: 10.1002/(sici)1099-1387(200001)6:1<11::aid-psc229>3.0.co;2-#

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✦ Synopsis

The solid phase synthesis of a set of peptide aldehydes derived from the NS5A/NS5B junction of hepatitis C virus (HCV) viral polyprotein is demonstrated using an oxazolidine linker and the Multipin™ method. Deletion of the P6 and P5 residues results in a dramatic loss of inhibitory activity.