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Proliferative effects of 12-O-Tetradecanoylphorbol-13-acetate (TPA) and calcium ionophores on human large granular lymphocytes (LGL)

✍ Scribed by Antonio Procopio; Angela Gismondi; Rossella Paolini; Stefania Morrone; Roberto Testi; Mario Piccoli; Luigi Frati; Ronald B. Herberman; Angela Santoni


Book ID
113134005
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
815 KB
Volume
113
Category
Article
ISSN
0008-8749

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## Abstract The effect of 12‐O‐tetradecanoylphorbol 13‐acetate (TPA) on human hematopoietic cells has been investigated. It was found that 1–10 ng/ml of TPA totally abrogated erythroid and granulocytic colony growth and, simultaneously in the presence of PHA, stimulated T‐lymphocyte colony formatio