Characterization of the response of human thymocytes and blood lymphocytes to the synergistic mitogenicity of 12-O-tetradecanoylphorbol-13-acetate (TPA) ionomycin
β Scribed by Domenico Delia; Melvyn Greaves; Silvia Villa; Filippo Debraud
- Book ID
- 102823004
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 658 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0014-2980
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## Abstract In the present work, we have inspected expression of estrogen receptors (ER) and their regulation by the phorbol diester 12βOβtetradecanoylphorbol 13βacetate (TPA) in a leukemic cell line, the THPβ1 cells, using multiple experimental approaches. Firstly, ligand binding assay (LBA) revea
We have previously reported that K562/ADM, a typical P-glycoprotein-mediated multi-drug-resistant cell line, is cross-resistant t o the growth-inhibitory effect of I 2 -0tetradecanoylphorbol I 3-acetate (TPA) and non-TPA type tumor promoters. To elucidate the mechanism of crossresistance to tumor pr