We evaluated the relationship among proliferation, death and migration of granule cells in lobules VI-VIII of vermis, in comparison with lobule III, during cerebellar development. To this aim, a single injection of cisplatin, i.e., a cytostatic agent that is known to induce death of proliferating gr
Proliferation of bergmann-glia in the developing rat cerebellum
✍ Scribed by Eduardo Bascó; Ferenc Hajós; Zoltán Fülöp
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 607 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0340-2061
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✦ Synopsis
Mitotic cells in the ganglionic layer of the infant rat cerebellum were studied between 3 to 12 postnatal days. The connection of these cells with the radial glial fibers of the primitive molecular layer could be established. On this basis it was assumed that the mitotic cells studied were immature Bergmann-glial cells whose proliferative activity seemed to continue even after the formation of their characteristic radial fibers. This phenomenon might offer an explanation for the divergent views on the generation time of Bergmann-glia.
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A mouse monoclonal ant,ibody to human chromogranin A (LK2H10) selectively stains the Bergmann glia (Golgi epithelial cells) of the rat cerebellum, while rabbit antibodies to bovine or porcine chromogranin A do not. Chromogranin A immunostaining in the cell bodies and processes reveals the characteri