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Human chromogranin A-like immunoreactivity in the bergmann glia of the rat brain

✍ Scribed by W. Geoffrey McAuliffe; Arthur Hess

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 464 KB
Volume: 3
Category: Article
ISSN: 0894-1491
DOI: 10.1002/glia.440030103

No coin nor oath required. For personal study only.

✦ Synopsis

A mouse monoclonal ant,ibody to human chromogranin A (LK2H10) selectively stains the Bergmann glia (Golgi epithelial cells) of the rat cerebellum, while rabbit antibodies to bovine or porcine chromogranin A do not. Chromogranin A immunostaining in the cell bodies and processes reveals the characteristic candelabra morphology seen in Golgi preparations of these cells. Immunostaining adjacent sections with antibodies to glial fibrillary acidic protein shows that a relatively small number of the glial cell processes in the molecular layer are chromogranin A positive. Recent reports indicate that the metabolites of chromogranin A play a regulatory role in endocrine and neuroendocrine systems but the function of chromogranins in neurons and glia is unknown.

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