Proliferation inhibition and apoptosis induction of imatinib-resistant chronic myeloid leukemia cells viaPPP2R5Cdown-regulation
β Scribed by Shen, Qi; Liu, Sichu; Chen, Yu; Yang, Lijian; Chen, Shaohua; Wu, Xiuli; Li, Bo; Lu, Yuhong; Zhu, Kanger; Li, Yangqiu
- Book ID
- 121623685
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 914 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1756-8722
No coin nor oath required. For personal study only.
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## Abstract The BcrβAbl inhibitor imatinib is the current firstβline therapy for all newly diagnosed chronic myeloid leukemia (CML). Nevertheless, resistance to imatinib emerges as CML progresses to an acute deadly phase implying that physiopathologically relevant cellular targets should be validat
## Abstract Bcrβabl signals for leukemogenesis of chronic myeloid leukemia (CML) and activates ras. Since the function of promyelocytic leukemia protein (pml) is provoked by ras to promote apoptosis and senescence in untransformed cells, the function is probably masked in CML. Imatinib specifically