579 Cytotoxic effects of resveratrol on imatinib sensitive and resistant K562 chronic myeloid leukemia cells
โ Scribed by G. Can; Y. Baran
- Book ID
- 119602360
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 47 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1359-6349
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## Abstract Although imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML), some patients develop resistance with progression of leukemia. Alternative or additional targeting of signaling pathways deregulated in bcrโablโdriven CML cells may provide a feasible opt
## Abstract The BcrโAbl inhibitor imatinib is the current firstโline therapy for all newly diagnosed chronic myeloid leukemia (CML). Nevertheless, resistance to imatinib emerges as CML progresses to an acute deadly phase implying that physiopathologically relevant cellular targets should be validat