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Proliferation and Differentiation of PC12 Cells Were Affected by p21rasGTPase Activating Proteins and Its Deletion Mutant Proteins

✍ Scribed by Hiroko Nakata; Yasuhiro Watanabe


Book ID
115577899
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
347 KB
Volume
218
Category
Article
ISSN
0006-291X

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## Abstract PC12 rat phaeochromocytoma cells show neuronal differentiation upon NGF treatment. NGF induces prolonged activation of the Ras/Raf/MEK/ERK pathway in which the 42/44 kDa mitogen‐activated protein kinases (MAPKs), ERK 1 and 2 are thought to be the key mediators of the differentiation sig