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Effects of overexpression of p21ras GTPase activating proteins and of expression of its deletion mutant proteins on proliferation and differentiation of rat pheochromocytoma PC12 cells

โœ Scribed by Nakata, Hiroko; Watanabe, Yasuhiro


Book ID
123242923
Publisher
Elsevier Science
Year
1994
Weight
130 KB
Volume
19
Category
Article
ISSN
0921-8696

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## Abstract PC12 rat phaeochromocytoma cells show neuronal differentiation upon NGF treatment. NGF induces prolonged activation of the Ras/Raf/MEK/ERK pathway in which the 42/44 kDa mitogenโ€activated protein kinases (MAPKs), ERK 1 and 2 are thought to be the key mediators of the differentiation sig