Proliferating cell nuclear antigen in the assessment of Barrett's mucosa

✍ Scribed by P. Gillen; M. McDermott; D. Grehan; D. O'B. Hourihane; T. P. J. Hennessy

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 462 KB
• Volume: 81
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800811219

✦ Synopsis

Proliferating cell nuclear antigen (PCNA) expression was tissue was significantly different from that of benign assessed in oesophageal epithelium from 70 patients with (P<O-Ool) and dysplastic (P<@05) specimens. PCNA Barrett's oesophagus. PCNA counts were expressed in the indices in histologically normal Barrett's epithelium form of a PCNA index. There were 24 patients with adjacent to a tumour were significantly Merent (P< 0.001) dysplastic epithelium, nine with regenerative atypia, 18 from those in normal Barrett's epithelium with no adjacent with benign histology and 19 with adenocarcinoma arising tumour. These findings support the use of PCNA in Barrett's epithelium. The PCNA index of malignant measurement in the assessment of Barrett's epithelium.

Barrett's mucosa is a metaplastic columnar epithelium of the oesophagus that develops as a result of chronic gastrooesophageal reflux'. Patients with Banett's mucosa have a