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Progressive multifocal leukoencephalopathy from JC virus in a patient with advanced mycosis fungoides

โœ Scribed by Jin Lee; Stephen K. Richardson; Elias R. Melhem; Alain H. Rook; Ellen J. Kim


Book ID
116583294
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
285 KB
Volume
57
Category
Article
ISSN
1097-6787

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A case of acute progressive multifocal leukoencephalopathy (PML) with hyper IgM syndrome 1 is reported. Viral DNA and VP1 protein of JC virus (JCV) and BK virus (BKV) were detected by immunohistochemistry, in situ hybridization, seminested polymerase chain (PCR) and PCR-restriction enzyme analysis.

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## Abstract Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, which is thought to be a result of the reactivation of JC virus (JCV), a human polyomavirus. The disease occurs in individuals with immunosuppression and in recent years there has