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Molecular characterization of JC virus (JCV) from HIV-infected Indian patients with progressive multifocal leukoencephalopathy (PML)

✍ Scribed by J. Marino; S. Shankar; P. Satishchandra; A. Mahadevan; T. C. Yasha; S. Ganju; T. Bui; V. Nerurkar

Book ID
111739264
Publisher
Springer US
Year
2004
Tongue
English
Weight
66 KB
Volume
10
Category
Article
ISSN
1355-0284

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## Abstract Progressive Multifocal Leukoencephalopathy (PML) is a severe and fatal demyelinating disease that occurs especially in HIV‐infected patients. It has been suggested that JC virus (JCV) migrates in peripheral blood leukocytes from the kidney to the central nervous system where it initiate

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A case of acute progressive multifocal leukoencephalopathy (PML) with hyper IgM syndrome 1 is reported. Viral DNA and VP1 protein of JC virus (JCV) and BK virus (BKV) were detected by immunohistochemistry, in situ hybridization, seminested polymerase chain (PCR) and PCR-restriction enzyme analysis.