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Progress toward the Total Synthesis of Ciguatoxins: A Convergent Synthesis of the FGHIJKLM Ring Fragment

โœ Scribed by Takakura, Hiroyuki; Sasaki, Makoto; Honda, Shugo; Tachibana, Kazuo


Book ID
125546727
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
78 KB
Volume
4
Category
Article
ISSN
1523-7060

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Convergent synthesis of the EFGH ring fr
โœ Hiroto Imai; Hisatoshi Uehara; Masayuki Inoue; Hiroki Oguri; Tohru Oishi; Masahi ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 95 KB

A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal C O bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F