Progress toward the synthesis of the transtaganolide/basiliolide natural products: an Ireland–Claisen approach
✍ Scribed by Hosea M. Nelson; Brian M. Stoltz
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 290 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Efforts toward the synthesis of the transtaganolide natural product family are described. A highly efficient Ireland-Claisen/Diels-Alder approach has been developed, which rapidly constructs the highly oxygenated and stereochemically rich core of these natural products.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
As estimated by 1 H NMR analysis, thermal isomerisation of the kinetic silylenolate derived from the ester (Z)-8a proceeds with acceptable diastereo and facial selectivity, thence affording an acid having the required absolute configuration for further elaboration to brassinosteroids.