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Progress in the design of DNA sequence-specific lexitropsins

✍ Scribed by Wynn L. Walker; Mary L. Kopka; David S. Goodsell

Publisher
Wiley (John Wiley & Sons)
Year
1997
Tongue
English
Weight
463 KB
Volume
44
Category
Article
ISSN
0006-3525

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✦ Synopsis

Sequence-specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure-based design of minor-groove-binding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences.

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