Prognostic value of cytogenetics in adult patients with Philadelphia-negative acute lymphoblastic leukemia
✍ Scribed by Inés Gómez-Seguí; Jose Cervera; Esperanza Such; David Martínez-Cuadrón; Irene Luna; Mariam Ibáñez; María López-Pavía; Adriana Gascón; Mónica Roig; Jesús Martínez; Jaime Sanz; Pau Montesinos; Guillermo Martín-Aragonés; Ignacio Lorenzo; Leonor Senent; Eva Barragán; Lourdes Cordón; Amparo Sempere; Guillermo F. Sanz; Miguel Angel Sanz
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 174 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0939-5555
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Cytogenetic analysis was made at diagnosisin 174 cases of ALL (101 children less than 20 years and 73 adults), excluding Burkitt's ALL (L3). In 11 children (1 1 per cent) insufficient material was obtained. In the remaining 90, 50 (56 per cent) had a normal karyotype, 20 (22 per cent) a hyperdiploid
## Background: Loss of heterozygosity (loh) at the atm gene (mutated in ataxia telangiectasia [at] patients) and atm protein deficiency occur in 14% and 34%, respectively, of patients with chronic lymphocytic leukemia (cll). atm protein deficiency also is associated with aggressive disease and wors