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Prognostic significance of thymidylate synthase in patients with metastatic colorectal cancer who receive protracted venous infusions of 5-fluorouracil

โœ Scribed by Ayumu Hosokawa; Yasuhide Yamada; Yasuhiro Shimada; Kei Muro; Tetsuya Hamaguchi; Hideko Morita; Mari Araake; Hiromi Orita; Kuniaki Shirao


Publisher
Springer
Year
2004
Tongue
English
Weight
210 KB
Volume
9
Category
Article
ISSN
1341-9625

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## Abstract Cytotoxic effect of 5โ€fluorouracil 5โ€FU is mediated through inhibition of thymidylate synthase (TS), and 5โ€FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5โ€FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30