The prognostic significance of thymidyla
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Sรธren Astrup Jensen; Ben Vainer; Jens Benn Sรธrensen
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Article
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2006
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John Wiley and Sons
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French
โ 350 KB
## Abstract Cytotoxic effect of 5โfluorouracil 5โFU is mediated through inhibition of thymidylate synthase (TS), and 5โFU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5โFU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30