✦ LIBER ✦

Prognostic significance of regulatory T cells in tumor

✍ Scribed by Cailin Moira Wilke; Ke Wu; Ende Zhao; Guobin Wang; Weiping Zou

Publisher: John Wiley and Sons
Year: 2010
Tongue: French
Weight: 183 KB
Volume: 127
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.25464

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Since entering the immunological stage several decades ago, regulatory T cell biology has been realized as fundamentally important in the prevention of autoimmune conditions, induction of transplant tolerance and the immune response to cancer. The role of regulatory T cells in tumor immunobiology is still being elucidated. Currently, regulatory T cells are implicated in the dampening of antitumor T‐cell responses both through direct and indirect means. A number of investigators have demonstrated that regulatory T cell density and location may serve as independent prognostic factors in several types of cancer and are alternately detrimental or beneficial to patient survival. In this article, we will review the characteristics and functional phenotype of classical regulatory T cells, describe their distribution and quantification in tumor‐bearing hosts and summarize recent studies investigating the prognostic significance of regulatory T cell number and locality in various cancers.

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