𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prognostic significance of prostaglandin E2 production in fresh tissues of head and neck cancer patients

✍ Scribed by Dr. Carl H. Snyderman; Ms. Michele Milanovich; Ms. Robin L. Wagner; Dr. Jonas T. Johnson

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
536 KB
Volume
17
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Immunosuppressive prostaglandins may play a role in the biologic behavior of head and neck cancer. Increased levels of prostaglandin E, (PGE,) have been measured in squamous cell carcinoma of the head and neck (SCCHN).

Methods. To address this question, tissue levels of PGE, were measured in tumor tissues, normal mucosa, and lymph nodes of 37 patients undergoing tumor resections. Tissue specimens were placed in culture media, and levels of PGE, released into the supernatant were measured by radioimmunoassay.

Results. Tissue levels of PGE, were significantly greater in tumor and normal mucosal tissues compared to lymph nodes (p = 0.0003). There was no difference between metastatic and tumor-free lymph nodes. Although tumor tissue levels of PGE, were not associated with tumor stage, increased levels of PGE, were associated with increased 2-year disease-free survival (p = 0.02).

πŸ“œ SIMILAR VOLUMES

Recurrence at the primary site in head a
Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor
✍ Charles R. Leemans; Rammohan Tiwari; Jos J. P. Nauta; Isaac Van Der Waal; Gordon πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 347 KB πŸ‘ 2 views

Background. Biologic aggressiveness of head and neck carcinoma is reflected in its capability to metastasize to regional lymph nodes and its propensity to recur after treatment. Methods. The authors report on 244 patients treated at the Department of Otolaryngology-Head and Neck Surgery of the Free

Loss of heterozygosity on chromosome 2q:
Loss of heterozygosity on chromosome 2q: Possibly a poor prognostic factor in head and neck cancer
✍ David T. Ransom; Timothy C. Barnett; Joan Bot; Bastiaan de Boer; Cecily Metcalf; πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 93 KB πŸ‘ 2 views

Background. Loss of heterozygosity (LOH) correlates with inactivated tumor suppressor genes. The aim of this study was to see if LOH on chromosomes 2q, 3p, 5q, 9p, and 17p correlated with survival in early squamous cell carcinoma of the head and neck (SCCHN). Methods. A case control study was perfo

Prognostic significance of cyclooxygenas
Prognostic significance of cyclooxygenase-2 expression and nuclear p53 accumulation in patients with colorectal cancer
✍ Sung-Chul Lim; Tae-Bum Lee; Cheol-Hee Choi; So-Yeon Ryu; Young-Don Min; Kyung-Jo πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 257 KB

## Abstract ## Background Cyclooxygenase (COX)‐2 is believed to be an important enzyme related to the pathogenesis of colorectal cancer (CRC). p53 has been reported to be a negative regulator of COX‐2 expression in in vitro studies. The aim of this study was to investigate COX‐2 expression and its

Prognostic significance of serum p53 pro
Prognostic significance of serum p53 protein and p53 antibody in patients with surgical treatment for head and neck squamous cell carcinoma
✍ Vivian Chow; Anthony Po Wing Yuen; King Yin Lam; Wai Kuen Ho; William Ignace Wei πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 79 KB πŸ‘ 1 views

## Abstract ## Objectives This study aims at investigating the prognostic values of serum p53 protein and anti‐p53 antibody in patients undergoing surgical treatment for head and neck squamous cell carcinoma (HNSCC). ## Methods Serum p53 protein and anti‐p53 antibody concentrations were determin