𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prognostic significance of p16/cdkn2a loss in pleural malignant mesotheliomas

✍ Scribed by Sanja Dacic; Hannelore Kothmaier; Stephanie Land; Yongli Shuai; Iris Halbwedl; Patrizia Morbini; Bruno Murer; Camilla Comin; Françoise Galateau-Salle; Funda Demirag; Handan Zeren; Richard Attanoos; Alan Gibbs; Philip Cagle; Helmut Popper

Publisher
Springer
Year
2008
Tongue
English
Weight
349 KB
Volume
453
Category
Article
ISSN
1432-2307

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Prognostic significance of CDKN2A (p16)
Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review
✍ Kaori Shima; Katsuhiko Nosho; Yoshifumi Baba; Mami Cantor; Jeffrey A. Meyerhardt 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 405 KB

## Abstract A cyclin‐dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A

Predicting functional significance of ca
Predicting functional significance of cancer-associated p16INK4a mutations in CDKN2A
✍ Heather A. McKenzie; Carina Fung; Therese M. Becker; Mal Irvine; Graham J. Mann; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 350 KB 👁 1 views

Inherited mutations affecting the INK4a/ARF locus (CDKN2A) are associated with melanoma susceptibility in 40% of multiple case melanoma families. Over 60 different germline INK4a/ARF mutations have been detected in more than 190 families worldwide. The majority of these alterations are missense muta

Small deletions but not methylation unde
Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma
✍ Alexander B. Mohseny; Chris Tieken; Pieter A. van der Velden; Karoly Szuhai; Car 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB

## Abstract Conventional osteosarcoma is characterized by rapid growth, high local aggressiveness, and metastasizing potential. Patients developing lung metastases experience poor prognosis despite extensive chemotherapy regimens and surgical interventions. Previously we identified a subgroup of os

The use of CDKN2A deletion as a diagnost
The use of CDKN2A deletion as a diagnostic marker for malignant mesothelioma in body cavity effusions
✍ Illei, Peter B. ;Ladanyi, Marc ;Rusch, Valerie W. ;Zakowski, Maureen F. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB

## Background: The distinction between benign reactive mesothelial cells and malignant mesothelial cells in serous effusions is difficult and has an unusually high false negative rate. unfortunately, there are no generally accepted markers to distinguish between benign reactive and malignant mesoth