Prognostic significance of FLT3 internal tandem repeat in patients with de novo acute myeloid leukemia treated with reinforced courses of chemotherapy
β Scribed by Boissel, N; Cayuela, J M; Preudhomme, C; Thomas, X; Grardel, N; Fund, X; Tigaud, I; Raffoux, E; Rousselot, P; Sigaux, F
- Book ID
- 110055180
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 216 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte
## Abstract ## BACKGROUND: A prognostic index to predict induction death in adult patients receiving induction chemotherapy for de novo acute myeloid leukemia (AML) was developed. ## METHODS: The authors analyzed 570 patients (aged 16β70 years) included in 2 multicenter trials of the CETLAM Grou