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Prognostic significance of DNA ploidy in male breast carcinoma. A retrospective analysis of 32 cases

✍ Scribed by Paolo Gattuso; Vijaya B. Reddy; Linda Green; Melanie Castelli; David Haley; Chester Herman

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 430 KB
Volume: 70
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19920815)70:4<777::aid-cncr2820700410>3.0.co;2-z

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Dna aneuploidy has been prognostically significant in female breast carcinoma of low stage, but its value in male breast carcinoma remains undetermined.

Methods:

Flow cytometric dna analyses were performed retrospectively on paraffin-embedded tissue from 32 men with breast carcinoma (mean follow-up time, 5.97 years [standard deviation +/- 4.63]; range, 1 to 18 years).

Results:

Multivariate discriminant function analysis showed only tumor size less than 2 cm to be independently predictive of better disease-free survival (p less than 0.05). dna ploidy (aneuploid, 25 patients; diploid, 7 patients) and lymph node status (positive, 22 patients; negative, 10 patients) were not predictive of survival, regardless of tumor size.

Conclusions:

The authors concluded that dna ploidy may not significantly predict survival in male breast carcinoma.

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