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Prognostic significance of dna measurement determined by image analysis in human breast carcinoma

✍ Scribed by Rabia Mir; Houston Johnson Jr.; Melissa Margolis; Steven Teplitz; Leslie Wise

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 390 KB
Volume: 50
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930500308

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✦ Synopsis

Abstract

The nuclear DNA of human breast carcinoma cells was studied by image analysis using archival paraffin‐blocked tissues from two groups of patients with breast cancers. One group had survived > 10 years (N = 20) and the other <3 years (N = 26) after the initial diagnosis. Cellular preparations were made from pepsin‐digested deparaffinated sections. The nuclear DNA was stained with Feulgen stain and measured by a computerized image analysis system. The data show that in addition to nodal status the pattern of DNA histograms obtained from image analysis can provide powerful prognostic information in breast carcinoma. The prognostic value of DNA histogram patterns may be independent of nodal status. © 1992 Wiley‐Liss, Inc.

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