Prognostic significance of cytogenetically detected chromosome 21 anomalies in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study
โ Scribed by Linda D. Cooley; Saleen Chenevert; Jonathan J. Shuster; Dennis A. Johnston; Donald H. Mahoney; Andrew J. Carroll; Meenakshi Devidas; Stephen B. Linda; Stephen J. Lauer; Bruce M. Camitta
- Book ID
- 113513119
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 117 KB
- Volume
- 175
- Category
- Article
- ISSN
- 0165-4608
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## Background: The authors have determined the prognostic significance of cytogenetically detectable 12p abnormalities, which are frequent in children with acute lymphoblastic leukemia (all), in a large cohort of patients treated on risk-adjusted protocols of the children's cancer group (ccg). ##
2-Deoxycoformycin (DCF) was added to an intensive Pediatric Oncology Group protocol (#8303) for children with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma in first relapse. Twenty-seven patients received one or more courses of DCF at 15 mg/m2/day as a 3-day continuous infusio