Late effects in survivors of childhood acute lymphoblastic leukemia: a study from Thai Pediatric Oncology Group
โ Scribed by Samart Pakakasama; Gavivann Veerakul; Darin Sosothikul; Su-on Chainansamit; Vichai Laosombat; Pattra Thanarattanakorn; Rachata Lumkul; Surapon Wiangnon; Somporn Wangruangsathit; Nattee Narkbunnam; Somjai Kanjanapongkul
- Book ID
- 107619045
- Publisher
- Carden Jennings Publishing
- Year
- 2010
- Tongue
- English
- Weight
- 151 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0925-5710
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Mutations at codon I 2, I 3, and 6 I of the HRAS, KRAS, and NRASgenes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, I 3 in the KRAS gene, a
2-Deoxycoformycin (DCF) was added to an intensive Pediatric Oncology Group protocol (#8303) for children with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma in first relapse. Twenty-seven patients received one or more courses of DCF at 15 mg/m2/day as a 3-day continuous infusio