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Prognostic relevance ofKRASandBRAFmutations in Japanese patients with colorectal cancer

โœ Scribed by Nakanishi, Ryota; Harada, Jun; Tuul, Munkhbold; Zhao, Yan; Ando, Koji; Saeki, Hiroshi; Oki, Eiji; Ohga, Takefumi; Kitao, Hiroyuki; Kakeji, Yoshihiro; Maehara, Yoshihiko


Book ID
118151879
Publisher
Springer
Year
2012
Tongue
English
Weight
344 KB
Volume
18
Category
Article
ISSN
1341-9625

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## Abstract Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFฮฒ signaling by SMADs. Following the definition of __SMAD4__ deletion as a negative pre