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357. Prognostic Markers in Patients with Metastatic Colorectal Cancer

โœ Scribed by Belyaeva, A.; Moiseenko, A.; Tsicoridze, M.; Karachun, A.; Gulyaev, A.


Book ID
123432013
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
37 KB
Volume
38
Category
Article
ISSN
0748-7983

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## Abstract Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFฮฒ signaling by SMADs. Following the definition of __SMAD4__ deletion as a negative pre