✦ LIBER ✦

Prognostic relevance of the intrinsic growth deceleration of the first passage xenografts of human renal cell carcinomas

✍ Scribed by Ioannis D. Bassukas; Georg Hofmockel; Panagiotis Tsatalpas; Victor Eberle; Brigitte Maurer-Schultze

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 291 KB
Volume: 78
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19961115)78:10<2170::aid-cncr19>3.0.co;2-w

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Although successful xenotransplantation of human tumors in nude mice highly predicts prognosis, little is known regarding the biologic background of this correlation. in this study, the relationship between the macroscopic growth pattern of first-generation xenografts of human renal cell carcinomas in nude mice and prognosis was studied.

Methods:

Macroscopic growth patterns of the first-generation xenografts of locally confined renal cell carcinomas were analyzed according to the best-fit gompertz recursion formulas.

Results:

The parameter "b" of the growth pattern, the measure of the intensity of growth deceleration as a function of tumor growth, strongly predicted prognosis after nephrectomy as a single factor; faster growth deceleration, i.e., lower b values, predicted better prognosis (mean follow-up, 5.2 years; p = 0.000008 for the disease free period and p = 0.000018 for overall survival). it is also the most significant single prognostic parameter among others (including staging and grading) according to a multivariate analysis.

Conclusions:

The parameter expressing the gompertzian macroscopic growth deceleration of the first-generation xenografts of clinically locally confined renal cell carcinomas in nude mice explains the strong prognostic impact of xenotransplantation.

📜 SIMILAR VOLUMES

Expression parameters of the inhibitors

Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance

✍ Carsten Kempkensteffen; Stefan Hinz; Frank Christoph; Jens Köllermann; Hans Krau 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 226 KB

## Abstract The expression of the inhibitor of apoptosis (IAP) family members cIAP1 and cIAP2 have been shown to be altered in various cancer entities. This study was done to characterize the tumor‐related expression profile of cIAP1 and cIAP2 in patients with renal cell carcinomas (RCC) and to eva

Prognostic relevance of the mTOR pathway

Prognostic relevance of the mTOR pathway in renal cell carcinoma : Implications for molecular patient selection for targeted therapy

✍ Allan J. Pantuck; David B. Seligson; Tobias Klatte; Hong Yu; John T. Leppert; La 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 980 KB

## Abstract ## BACKGROUND. The mammalian target of rapamycin (mTOR) pathway is up‐regulated in many human cancers, and agents targeting the mTOR pathway are in various stages of clinical development. The goal of the study was to evaluate the potential and limitations of targeting the mTOR pathway

Amplification and overexpression of the

Amplification and overexpression of the epidermal growth factor receptor gene in human renal-cell carcinoma

✍ Jiro Ishikawa; Sakan Maeda; Kei-Ichi Umezu; Taketoshi Sugiyama; Sadao Kamidono 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 512 KB

We examined 22 cases of renal-cell carcinoma (RCC) for structural alterations of the epidermal growth factor receptor (ECFR) gene and found gene amplification in one case of high-stag+high-grade RCC. Dot blot analysis of the total RNA from tumorous and normal kidney tissues revealed overexpression o

Growth and characterization of a cell li

Growth and characterization of a cell line from a human primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma) in culture and as xenograft

✍ Konstantin Krasagakis; Brigitte Almond-Roesler; Christoph Geilen; Sabine Fimmel; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB

## Abstract The primary neuroendocrine carcinoma of the skin or Merkel cell carcinoma (MCC) is a skin tumor with aggressive biological behaviour. Experimental models for investigating the biological properties of the tumor are prerequisite for developing new therapeutic approaches. In this study, w

Sesquiterpene lactone parthenolide suppr

Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-κB

✍ Daizo Oka; Kazuo Nishimura; Masahiro Shiba; Yasutomo Nakai; Yasuyuki Arai; Masas 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 459 KB

## Abstract The transcription factor nuclear factor‐κB (NF‐κB) has been shown to be constitutively activated in various human malignancies, including leukemia, lymphoma and a number of solid tumors. NF‐κB regulates the transcriptional of genes important for tumor invasion, metastasis and chemoresis

Expression of the free β-subunit of huma

Expression of the free β-subunit of human chorionic gonadotropin in renal cell carcinoma: Prognostic study on tissue and serum

✍ Kristina Hotakainen; Börge Ljungberg; Caj Haglund; Stig Nordling; Annukka Paju; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 153 KB

Expression of the free beta-subunit of human chorionic gonadotropin (hCGbeta) in malignant tumors is frequently associated with aggressive disease. We have shown previously that the pretreatment serum concentration of hCGbeta is an independent prognostic variable in patients with renal cell carcinom