Prognostic relevance of p53 mutation in colorectal carcinoma
✍ Scribed by Öfner, Dietmar; Schmid, Kurt Werner
- Book ID
- 122385243
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 126 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
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## Abstract The influence of __p53__ mutations on the response to ionizing radiation and survival was retrospectively evaluated in patients treated with preoperative radiotherapy for rectal carcinoma. From 1989 to 1991, 86 rectal cancer patients treated by preoperative radiotherapy were included in
p53 gene mutations in early and advanced colorectal cancer were detected by PCR-SSCP analysis. Early colorectal cancer was classified into de novo cancer and polypforming cancer, respectively, according to morphology and presence of adenomatous components. A total of 94 paraffin-embedded tissue spec