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Prognostic markers of ourcome in non-acetaminophen overdose fulminant hepatic failure

โœ Scribed by Dabos, Konstantinos J.; Newsome, Philip N.; Parkinson, John a.; Sadler, Ian H.; Plevris, John N.; Hayes, Peter C.

Book ID
123406645
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
244 KB
Volume
124
Category
Article
ISSN
0016-5085

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An improved model of acetaminophen-induc
An improved model of acetaminophen-induced fulminant hepatic failure in dogs
โœ James H. Kelly; Tarek Koussayer; Da-Er He; Maria G. Chong; Thomas A. Shang; Hart ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 920 KB

We have established an improved model of fulminant hepatic failure in dogs. Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 pg/ml for 20 hr. This regimen produces sever