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Prognostic implication of strong expression of the smad ubiquitin ligase smurf2 in human pancreatic cancer

โœ Scribed by A. Kida; K. Nagai; D. Ito; K. Kami; M. Koizumi; E. Toyoda; T. Mori; Y. Kawaguchi; K. Fujimoto; R. Doi

Book ID
116702427
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
69 KB
Volume
130
Category
Article
ISSN
0022-4804

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## Abstract The expression of Skp2, the ubiquitin ligase subunit that targets p27^Kip1^ for degradation, is commonly overexpressed in human cancers. p27^Kip1^ is a negative regulator of the cell cycle that plays an important role in tumor suppression. Loss of p27^Kip1^ secondary to enhanced ubiquit